Week 5 College Football Picks: Expert Predictions Against the Spread

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Week 5 of college football is here. Fans are buzzing about the matchups and betting lines.

This week, our picks come from a sports analyst with a 23-14 record against the spread. There are powerhouse teams, some underdogs, and a handful of games that should be pretty exciting. Let’s check out the analysis and picks for this week’s top college football games.

Louisville vs. Pittsburgh

The Louisville Cardinals are taking on the Pittsburgh Panthers. Louisville is favored by 3.5 points, and the over/under sits at 55.5.

Game Analysis

Louisville’s been doubted a lot. They’re hoping to quiet the critics this week.

Key players like Isaac Brown, Duke Watson, Rene Konga, and Wes Bailey are all game-time decisions. That could change things quite a bit. Prediction: Louisville pulls out a 34-27 win.

Indiana vs. Iowa

Indiana heads to Iowa, holding an 8.5-point advantage. The over/under is set at 47.5.

Game Analysis

Indiana’s offense, led by Fernando Mendoza and a solid group of receivers, looks set to outpace Iowa. The pick here is Indiana, 28-17.

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WKU vs. Missouri State

Western Kentucky University is favored by 3.5 points against Missouri State. The over/under is a high 59.5.

Game Analysis

WKU has won nine straight as a September favorite. Even with some worries about being on the road, their offense should be enough for a 35-31 win.

Alabama vs. Georgia

Alabama faces Georgia in a big matchup. Georgia is favored by 2.5 points, with an over/under of 53.5.

Game Analysis

Georgia has a crazy home record: 33 straight wins. The prediction is Georgia takes it, 28-21.

Oregon vs. Penn State

Oregon goes to Penn State as a 3.5-point underdog. The over/under is 53.5.

Game Analysis

Oregon is picked to win, 31-28. That would be a big statement, especially away from home.

Kentucky vs. South Carolina

Kentucky travels to South Carolina as a 5.5-point underdog. The over/under is 47.5.

This one’s huge for Kentucky—they’re still chasing their first SEC win of the season.

Game Analysis

With a prediction of a 24-17 win for Kentucky, this game could really swing on whether they can keep their running game moving. They’ll also need to avoid giving up big plays on special teams, which, honestly, is easier said than done.

This matchup will challenge South Carolina’s defense, especially when it comes to tackling. If they slip up there, it might get ugly fast.

For a more detailed breakdown of these picks and to stay updated on the latest college football news, check out the full article on WDRB Sports.

Joe Hughes
Joe Hughes is the founder of CollegeNetWorth.com, a comprehensive resource on college athletes' earnings potential in the NIL era. Combining his passion for sports with expertise in collegiate athletics, Joe provides valuable insights for athletes, fans, and institutions navigating this new landscape.

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