As the 2025 college football season rolls on, Week 7 is shaping up to be a wild one. After a Week 6 full of surprises—hello, Texas and Penn State both falling to unranked teams—fans are buzzing with anticipation.
This week brings a huge Big Ten clash between Oregon and Indiana. There are also several games featuring ranked teams that could get interesting fast.
Our college football crew has weighed in with their picks against the spread for the top matchups. If you’re looking for some insight (or just want to see who’s bold enough to call an upset), you’re in the right place.
Key Matchups and Expert Picks
Week 7 is packed with games that could swing the season. Let’s check out the big ones and see how the experts are leaning.
North Texas vs. South Florida
This one opened with North Texas as a 2.5-point favorite, but the line’s moved since. Honestly, the experts can’t agree:
- Blake Schuster: North Texas +1.5
- Christian D’Andrea: North Texas +1.5
- Michelle Martinelli: North Texas +1.5
- Tyler Nettuno: South Florida -1.5
- Prince Grimes: South Florida -1.5
North Texas has shown they can score with just about anyone in the Group of 5. Still, South Florida’s got some serious momentum and remains in the CFP conversation, so this one’s tough to call.
Ohio State vs. Illinois
Ohio State is a 13.5-point favorite against Illinois, at least according to the opening line. Here’s how the picks shake out:
- Blake Schuster: Illinois +14.5
- Christian D’Andrea: Illinois +14.5
- Michelle Martinelli: Ohio State -14.5
- Tyler Nettuno: Ohio State -14.5
- Prince Grimes: Illinois +14.5
Ohio State is stacked, but Illinois has a defense that can make things interesting. Luke Altmyer at quarterback gives them a fighting chance to keep it close, or at least closer than that spread.
Alabama vs. Missouri
Alabama’s favored by 6.5 over Missouri, but all our experts are on the same page:
- Blake Schuster: Alabama -3
- Christian D’Andrea: Alabama -3
- Michelle Martinelli: Alabama -3
- Tyler Nettuno: Alabama -3
- Prince Grimes: Alabama -3
Ty Simpson is running the offense for Alabama, and that’s bad news for Missouri’s defense. Missouri will have to dig deep to keep up, but the Tide look like a safe bet to cover.
Florida State vs. Pittsburgh
Florida State opened as an 8.5-point favorite, but the line moved a bit. Here’s what the experts think:
- Blake Schuster: Florida State -10.5
- Christian D’Andrea: Pittsburgh +10.5
- Michelle Martinelli: Florida State -10.5
- Tyler Nettuno: Pittsburgh +10.5
- Prince Grimes: Florida State -10.5
Florida State’s had some turnover issues lately, but most expect them to get back on track at home. Pittsburgh’s defense is no pushover, though, so it might not be a total blowout.
Marquee Matchup: Oregon vs. Indiana
The big one this week is Oregon vs. Indiana in the Big Ten. Oregon started out as a 14-point favorite, but that’s shifted. Here’s where the experts landed:
- Blake Schuster: Indiana +7.5
- Christian D’Andrea: Indiana +7.5
- Michelle Martinelli: Oregon -7.5
- Tyler Nettuno: Oregon -7.5
- Prince Grimes: Indiana +7.5
Indiana’s shown some grit this year, and some folks think they can keep it tight. Then again, playing at Autzen Stadium is brutal, and Oregon’s depth might just tip the scales.
Other Notable Games
There are a few more games that could get weird or wild:
- Texas vs. Oklahoma: Texas is having some issues, but the experts are split on whether Oklahoma can take advantage.
- Georgia vs. Auburn: Georgia’s the favorite, but Auburn’s defense could turn this into a nail-biter.
- Michigan vs. USC: Feels like a trap for Michigan, honestly. USC’s offense is no joke.
- LSU vs. South Carolina: LSU’s favored, but South Carolina might be out for revenge and could keep it close.
- Utah vs. Arizona State: Utah’s the favorite, but Arizona State has been through the wringer and could surprise everyone.
Conclusion
Week 7 of the 2025 college football season looks like it could be a wild one. There are a bunch of interesting matchups and maybe even a few upsets brewing.
Fans should keep an eye on the expert picks—sometimes they really do call it! If you’re hungry for more details or just want to dive deeper, the full article’s over at USA Today.
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