Big 12 Week 10 Football Predictions and Game Picks

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The excitement is hard to miss as we roll into Week 10 of Big 12 college football. Fans and analysts are buzzing about matchups that could really shake up the rest of the season.

Key games on the slate include UCF at Baylor, Arizona at Colorado, and West Virginia at Houston. The Arizona Republic’s expert predictions are in, so let’s see what might unfold.

Big 12 Week 10 Matchups and Predictions

This week’s Big 12 schedule has a few games that could seriously impact the conference standings. Some of these matchups are just plain intriguing.

West Virginia at Houston

Saturday, Nov. 1, 9 a.m., FS1 (stream with FUBO)

The Houston Cougars have surprised a lot of people in the Big 12 this year. Quarterback Conner Weigman is leading the charge, and Houston looks like they might keep rolling against West Virginia.

The Mountaineers have had a tough go of it, and honestly, nobody would be shocked if Houston wins this one comfortably.

  • Prediction: Houston 30, West Virginia 17

UCF at Baylor

Saturday, Nov. 1, 9 a.m., ESPNU (stream with FUBO)

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Baylor is trying to recover after dropping two straight. At 2-3 in the Big 12, the Bears are hungry to even things up in conference play.

Quarterback Sawyer Robertson is expected to step up and give Baylor the edge over UCF. It’s a big spot for him.

  • Prediction: Baylor 33, UCF 24

Arizona State at Iowa State

Saturday, Nov. 1, 10 a.m., TNT (stream with Sling)

This one’s been circled on Iowa State’s calendar for a while. After getting knocked off by Arizona State in last season’s Big 12 title game, the Cyclones are itching for payback.

It’s probably going to be a tight game, but Iowa State should squeak it out.

  • Prediction: Iowa State 27, Arizona State 24

Texas Tech at Kansas State

Saturday, Nov. 1, 12:30 p.m., FOX (stream with FUBO)

Kansas State stumbled out of the gate but has managed to right the ship, now sitting at 3-2 in Big 12 play. Texas Tech’s quarterback Behren Morton isn’t coming to play nice, though.

This one feels like it could go either way, but it should be a fun watch.

  • Prediction: Texas Tech 27, Kansas State 20

Oklahoma State at Kansas

Saturday, Nov. 1, 1 p.m., ESPN+ (stream with ESPN+)

Kansas has let fans down a few times this season, but let’s be real—they’re still a step above the 1-7 Oklahoma State Cowboys. Jalon Daniels and the Jayhawks are in a good spot to pick up a win they really need.

  • Prediction: Kansas 38, Oklahoma State 20

Arizona at Colorado

Saturday, Nov. 1, 4 p.m., FS1 (stream with FUBO)

Arizona is coming off a bye and hoping to snap a two-game skid. They haven’t won on the road yet this season, which is… not great.

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But with some rest and Colorado reeling from a tough loss to Utah, maybe this is the moment things turn around for the Wildcats.

  • Prediction: Arizona 27, Colorado 24

Cincinnati at Utah

Saturday, Nov. 1, 7:15 p.m., ESPN (stream with FUBO)

Cincinnati’s 7-1 overall and 5-0 in the Big 12, but somehow they’re underdogs against Utah. The Bearcats keep getting overlooked, and honestly, it kind of feels unfair.

Utah’s Devon Dampier is expected to make the difference, though, and Cincinnati might finally take a conference loss here.

  • Prediction: Utah 30, Cincinnati 27

Key Takeaways

Week 10 in Big 12 football is shaping up to be a wild ride. There are some matchups on the schedule that could really shake things up.

Houston’s looking to keep their hot streak alive. Meanwhile, Baylor’s got something to prove and maybe a little pride to reclaim.

Every game this weekend seems to have its own twist. Fans are probably in for a few surprises, and the conference standings could look pretty different by the end of it all.

Want more in-depth predictions? Check out the full article on The Arizona Republic.

Joe Hughes
Joe Hughes is the founder of CollegeNetWorth.com, a comprehensive resource on college athletes' earnings potential in the NIL era. Combining his passion for sports with expertise in collegiate athletics, Joe provides valuable insights for athletes, fans, and institutions navigating this new landscape.

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