Top College Football Playoff Quarterfinal Picks Against the Spread

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As the 2025 College Football Playoff quarterfinals draw near, the buzz is real. Fans and analysts can’t stop talking about the matchups, and honestly, who can blame them?

This year feels different. Powerhouse teams are going head-to-head, all chasing a shot at the semifinals.

Here, we’ll break down the key points of the quarterfinals with some honest analysis and predictions against the spread. Expect a look at each game, a few players to watch, and a rundown of the betting odds.

Let’s jump into the wild world of college football, shall we?

Quarterfinal Matchup Analysis

The quarterfinals are stacked with some of the most anticipated games of the season. Each matchup brings its own drama and twists.

Offensive strategies, defensive strengths—every detail seems to matter when you’re trying to predict these outcomes. It’s a lot to take in, but that’s what makes it fun.

Game 1: Alabama vs. Ohio State

Alabama versus Ohio State is shaping up to be a classic. Alabama’s offense has looked pretty unstoppable at times, but Ohio State’s defense isn’t exactly a pushover.

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Alabama’s quarterback has been electric all season, while Ohio State’s defensive lineman has a knack for wrecking plays. It’s a matchup that could swing either way, honestly.

Key Points:

  • Alabama’s high-scoring offense
  • Ohio State’s strong defensive line
  • Impact of turnovers on the game’s outcome

Game 2: Clemson vs. Notre Dame

Clemson and Notre Dame have history, and this quarterfinal is just adding another chapter. Clemson’s got a balanced attack, but Notre Dame’s defense is tough and unafraid.

The Clemson running back could be a difference-maker, while Notre Dame’s secondary will have their hands full. It’s hard to say who has the edge here.

Key Points:

  • Clemson’s versatile offense
  • Notre Dame’s defensive strategies
  • Special teams’ potential impact

Betting Insights and Predictions

Betting on college football? It’s a thrill, but not for the faint of heart. Knowing the spread and how these teams perform against it is key if you’re planning to put money down.

Let’s take a look at the odds and see where things might land for each quarterfinal.

Alabama vs. Ohio State: Betting Analysis

Alabama comes in as the favorite, but Ohio State’s defense could keep things interesting. The spread sits at Alabama -6.5, which feels about right given the matchup.

With Alabama’s offense and Ohio State’s defense, this one could go right down to the final minutes. Wouldn’t be shocking at all.

Betting Tips:

  • Consider Alabama’s track record in high-pressure games
  • Analyze Ohio State’s performance against top-tier offenses
  • Monitor injury reports leading up to the game

Clemson vs. Notre Dame: Betting Analysis

Clemson is favored by 4 points, but Notre Dame won’t roll over. Clemson’s offense is balanced, Notre Dame’s defense is gritty—makes for a tricky bet.

It might help to look at how both teams have handled tough opponents this year. Sometimes the details tell a different story than the odds do.

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Betting Tips:

  • Review Clemson’s performance in rivalry games
  • Examine Notre Dame’s defensive adjustments
  • Consider the impact of home-field advantage

Players to Watch

Big games are often decided by big performances. Here are a few players who could swing things in the quarterfinals:

Alabama vs. Ohio State

Alabama: The quarterback’s been the guy all season, making smart reads and delivering under pressure. If he gets hot, watch out.

Ohio State: That defensive lineman? He’s a menace. If he can get in Alabama’s backfield, things could get messy fast.

Clemson vs. Notre Dame

Clemson: The running back’s burst and quick feet make him a threat every snap. If he finds a seam, he can turn nothing into six points.

Notre Dame: The secondary’s got a tough job. If they can keep Clemson’s receivers in check, it’ll go a long way toward pulling off an upset.

Conclusion

The 2025 College Football Playoff quarterfinals are shaping up to be an unforgettable series of games. Powerhouse teams and standout players fill the field this year.

Fans are in for a treat. Even if you’re just tuning in out of curiosity, picking up on the key matchups and betting angles can make things a lot more interesting.

Want a deeper dive or maybe some picks against the spread? Check out the full article on the New York Times.

Keep an eye out for more updates, and honestly, just soak up the energy of college football season. It’s never quite the same twice.

Joe Hughes
Joe Hughes is the founder of CollegeNetWorth.com, a comprehensive resource on college athletes' earnings potential in the NIL era. Combining his passion for sports with expertise in collegiate athletics, Joe provides valuable insights for athletes, fans, and institutions navigating this new landscape.

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