Week 3 College Football Betting Picks and Odds for 2025

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The 2025 college football season is already heating up. Week 3 brings a lineup of games that fans and bettors can’t stop talking about.

From the big-name showdowns to those sneaky matchups flying under the radar, there’s plenty to get excited about. Let’s dig into the expert picks, betting lines, and trends shaping this wild week in college football.

Whether you’re a seasoned bettor or just a curious fan, there’s something here for everyone. Let’s get into it.

Table of Contents

Week 3 College Football Picks and Expert Analysis

This week’s schedule is full of matchups that could shift the season’s direction. Analysts have been poring over the odds and lines, looking for the best bets and hidden gems.

Some games between the top teams are drawing a ton of attention. And you never know—there’s always the chance for a surprise upset.

Top Matchups to Watch

Several high-stakes games headline the week. Here are a few that everyone’s talking about:

Alabama vs. Florida: Classic SEC battle. Both teams looked sharp last week, and this one could shake up the playoff picture.
Ohio State vs. Michigan State: The Buckeyes want to prove they’re playoff material. Michigan State’s hoping to play spoiler.
USC vs. Oregon: Huge Pac-12 clash. Both squads have firepower on offense, so this might turn into a shootout.

Betting Lines and Trends

Betting lines and trends are where things get interesting. Experts have sifted through the numbers and pointed out some patterns to watch in Week 3.

Against the Spread (ATS) Picks

Betting against the spread remains a favorite move for college football fans. Here are some expert ATS picks for this week:

Alabama (-7) vs. Florida: Crimson Tide is favored by seven. Experts think they can cover it, but it’s never a guarantee.
Ohio State (-10) vs. Michigan State: Buckeyes are heavy favorites. Their offense should put up enough points, but Michigan State isn’t a pushover.
USC (-3) vs. Oregon: Trojans are slight favorites. Their offense gives them a bit of an edge, though Oregon’s no slouch.

Over/Under Picks

Over/under bets keep things interesting. You’re betting on total points, not just who wins. Here’s what the experts are thinking for Week 3:

Alabama vs. Florida (O/U 55): Experts expect a high-scoring game, so the over looks tempting.
Ohio State vs. Michigan State (O/U 48): With Ohio State’s offense, the over is a popular pick here too.
USC vs. Oregon (O/U 62): Both teams can light up the scoreboard. Over is the trendy choice.

Expert Best Bets

If you’re hunting for value, some games stand out. Experts have their eyes on a few that could offer a nice return.

Underdog Picks

Betting on underdogs isn’t for the faint of heart, but it can pay off big. Here are a few that experts think have a shot this week:

Florida (+7) vs. Alabama: Alabama’s the favorite, but Florida has the pieces to keep it close—or maybe even steal it.
Michigan State (+10) vs. Ohio State: Spartans bring a tough defense. They might slow down the Buckeyes enough to cover.
Oregon (+3) vs. USC: Ducks have the offense to go toe-to-toe with USC. Don’t count them out in this one.

Prop Bets

Prop bets add another layer of fun. These focus on specific moments or performances within the game. Here are a few props worth a look for Week 3:

Alabama’s QB passing yards (O/U 300): Experts are leaning over here. Alabama’s quarterback could have a big day.
Ohio State’s total touchdowns (O/U 5): Their offense is explosive, so the over is a trendy pick.
USC’s total points (O/U 35): Trojans are expected to rack up points. The over seems pretty solid.

Conclusion

Week 3 of the 2025 college football season looks like it’ll be a wild ride. There’s a lot for bettors and fans to dig into.

If you want to get into the weeds with expert picks and betting lines, you’ve got options. Check out the full analysis here.

Joe Hughes is the founder of CollegeNetWorth.com, a comprehensive resource on college athletes' earnings potential in the NIL era. Combining his passion for sports with expertise in collegiate athletics, Joe provides valuable insights for athletes, fans, and institutions navigating this new landscape.

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