Week 6 College Football Predictions 2025: Top Matchups and Surprises

BOOK AWAY GAME TRAVEL NOW!
Flights | Hotels | Vacation Rentals | Rental Cars | Experiences

As the dust settles from a wild weekend in college football, Week 6 is shaping up to be another rollercoaster. There are several Top 25 matchups and a bunch of big conference games coming up.

The outcomes this week could really shake up the season. Let’s break down the most anticipated games, spotlight a few key players, and toss out some predictions. (If you want the full scoop, the Bleacher Report article has everything.)

Top 25 Matchups to Watch

Week 6 brings some high-stakes games that could mess with the rankings and playoff hopes. Here are the matchups I’m most interested in:

No. 14 Iowa State at Cincinnati

Iowa State is undefeated at 5-0 and heads to Cincinnati, who’s sitting at 3-1. The Cyclones aren’t huge favorites, but they’re hoping to keep their record perfect.

Cincinnati’s QB Brendan Sorsby is a real threat on the ground and through the air. Still, Iowa State’s balance gives them a slight advantage.

Prediction: Iowa State 23, Cincinnati 19

No. 9 Texas at Florida

The Longhorns, 3-1, travel to face a Florida team that’s been struggling at 1-3. Texas has a defense that’s tough as nails, and honestly, Florida’s defense is the only thing keeping them in games.

Advertisement
Advertisement

Feels like a low-scoring slugfest, but Texas should pull it out.

Prediction: Texas 24, Florida 10

No. 16 Vanderbilt at No. 10 Alabama

Alabama just beat Georgia and now hosts undefeated Vanderbilt. Vandy’s QB Diego Pavia has been fun to watch, but Alabama at home is a different animal.

Coach Kalen DeBoer’s squad just doesn’t lose in Tuscaloosa.

Prediction: Alabama 41, Vanderbilt 27

No. 3 Miami at No. 18 Florida State

Miami’s lines on both sides are relentless, while Florida State’s defense is always looking to force mistakes. If the Seminoles can rattle Miami QB Carson Beck, maybe there’s a chance for an upset.

Miami just feels a bit too physical, though.

Prediction: Miami 27, Florida State 20

Mississippi State at No. 6 Texas A&M

Mississippi State loves playing spoiler, but Texas A&M is unbeaten and playing at home. QB Marcel Reed has been solid for the Aggies.

That crowd at Kyle Field? It’s a tough place to pull off an upset.

Prediction: Texas A&M 38, Mississippi State 24

Friday Night Lights

Friday night brings a few matchups I’m curious about, including both ranked and unranked squads:

BOOK AWAY GAME TRAVEL NOW!
Find the best accommodations
Check availability at 5* hotels, guest houses and apartments rated "superb" or "exceptional" by visitors just like you.
NO RESERVATION FEES
CHECK AVAILABILITY FOR YOUR DATES HERE
 

West Virginia at No. 23 BYU

BYU’s QB Bear Bachmeier has been lights out, and the Cougars are 4-0. West Virginia’s defense has been a mess lately.

BYU looks like the clear favorite here.

Prediction: BYU 37, West Virginia 14

Sam Houston at New Mexico State

Two teams having a rough go of it. New Mexico State should squeak by in a close one.

Prediction: NMSU 23, Sam Houston 20

Charlotte at South Florida

South Florida’s offense can put up points fast. Charlotte’s defense just isn’t up for it this year.

Prediction: USF 42, Charlotte 14

Saturday Showdowns

Saturday’s schedule is stacked. Conference games, some out-of-conference drama—plenty to watch:

Wisconsin at No. 20 Michigan

Wisconsin’s offense has been sputtering, and now QB Billy Edwards Jr. is banged up. Michigan at home is a pretty easy pick.

Prediction: Michigan 27, Wisconsin 10

No. 22 Illinois at Purdue

Illinois is coming off an emotional, last-second win over USC. Purdue’s defense isn’t great, but Illinois needs to avoid a letdown here.

Prediction: Illinois 31, Purdue 24

No. 7 Penn State at UCLA

Penn State is heading cross-country to play a winless UCLA team. The Nittany Lions should handle business, even with the travel.

Prediction: Penn State 37, UCLA 17

No. 24 Virginia at Louisville

Virginia just shocked Florida State, but Louisville’s got a balanced offense and a defense that loves to force turnovers. Virginia’s defense could be in trouble again.

Prediction: Louisville 38, Virginia 27

No. 11 Texas Tech at Houston

Texas Tech’s QB Behren Morton will need to be sharp against Houston’s tough defense. Houston’s offense is a bit of a question mark, so I’m leaning Red Raiders here.

Prediction: Texas Tech 27, Houston 20

Other Notable Games

Here are a few others that might be worth flipping to during commercials:

  • Kentucky at No. 12 Georgia: Georgia’s defense should handle Kentucky’s struggling offense.
  • Boise State at No. 21 Notre Dame: Notre Dame’s offense has been clicking lately.
  • Coastal Carolina at Old Dominion: Old Dominion should win this one pretty comfortably.
  • Colorado at TCU: TCU’s offense is just too much for Colorado to keep up with.
  • Kansas at UCF: Kansas is the favorite on the road, but you never know in the Big 12.

Conclusion

Week 6 of the college football season is shaping up to be wild. There are some seriously intriguing matchups on the slate.

Several Top 25 teams are hitting the road, and honestly, a few upsets wouldn’t shock me. Conference games could really shake up the standings, too.

If you want every prediction and all the nitty-gritty analysis, the full article on Bleacher Report is worth a look.

Joe Hughes
Joe Hughes is the founder of CollegeNetWorth.com, a comprehensive resource on college athletes' earnings potential in the NIL era. Combining his passion for sports with expertise in collegiate athletics, Joe provides valuable insights for athletes, fans, and institutions navigating this new landscape.

    Additional Reading:
Advertisement
Advertisement
Scroll to Top