Week 6 College Football: Top 25 Picks, Odds, Predictions, and Schedule

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Week 6 of the college football season is shaping up to be a wild one. The Miami Hurricanes and Florida State Seminoles headline the action, and honestly, it’s about time we got this rivalry with both teams ranked—first time since 2016.

Miami sits at third in the nation and is the clear favorite for the ACC. Florida State, meanwhile, is still licking its wounds after a tough loss to Virginia, but they’re hungry for a comeback. This game could really shake up both teams’ seasons and maybe even the College Football Playoff picture.

Key Matchups to Watch

Sure, Miami vs. Florida State is the big ticket, but there’s more heat on the slate. These Top 25 matchups could get interesting fast:

  • No. 23 BYU vs. West Virginia – BYU’s got a hefty -19.5 spread.
  • No. 12 Georgia vs. Kentucky – Georgia is expected to roll with a -20.5 spread.
  • No. 14 Iowa State vs. Cincinnati – This one’s tight, Cincinnati slightly favored at -1.5.
  • No. 20 Michigan vs. Wisconsin – Michigan is sitting as -16.5 favorites.
  • No. 7 Penn State vs. UCLA – Penn State’s favored by a solid -24.5.
  • No. 9 Texas vs. Florida – Texas is at -7 here.
  • No. 10 Alabama vs. No. 16 Vanderbilt – Alabama’s favored by -10.5, but you never know.

Implications for the ACC and College Football Playoff

Florida State has a shot to claw back into playoff talks if they can knock off Miami. That overtime loss to Virginia still stings, but a win here could flip the script for their whole season.

Miami’s got a lot riding on this too. Quarterback Carson Beck is playing lights out—some are tossing around the word “Heisman”—and their defense has been stingy, giving up only 46 points in four games. Still, they’ve had some hiccups on the road, so Tallahassee won’t be a cakewalk.

Player to Watch: Tommy Castellanos

Keep an eye on Florida State’s quarterback, Tommy Castellanos. He already showed he can lead an upset, just look at what happened against Alabama in Week 1. If he’s on, Miami’s defense could have their hands full.

Defensive Adjustments Needed

Florida State’s defense needs to get it together. They gave up 46 points and 440 yards to Virginia—not exactly a confidence booster. If they don’t tighten up, Miami’s offense could have a field day.

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Other Notable Games

Don’t sleep on the rest of the weekend. There are a few more games that could get wild:

  • No. 21 Notre Dame vs. Boise State – Notre Dame is favored by -17.5.
  • No. 24 Virginia vs. Louisville – Virginia is at -7 here.
  • No. 5 Oklahoma vs. Kent State – Oklahoma’s supposed to cruise with a -45.5 spread.
  • No. 11 Texas Tech vs. Houston – Texas Tech is -12.5 favorites.
  • No. 1 Ohio State vs. Minnesota – Ohio State’s got a -24.5 edge.
  • No. 6 Texas A&M vs. Mississippi State – Texas A&M is favored by -14.

Predictions and Betting Odds

Bookmakers have Miami at -5.5 over Florida State, but there’s a lot of chatter that the Seminoles could keep it close—or even pull off a stunner. Castellanos’ cool under pressure might just tip the scales.

For Alabama vs. Vanderbilt, the Crimson Tide are -10.5 favorites. Alabama’s been rolling since that early stumble against Florida State, but Vanderbilt’s Diego Pavia has a knack for surprises. Worth tuning in, just in case.

Conclusion

Week 6 of the college football season is shaping up to be pretty wild. There are some high-stakes matchups on the horizon, and honestly, things could get shaken up for the ACC and the College Football Playoff.

The Miami vs. Florida State game? That’s the one everyone’s talking about. Still, it might be worth keeping an eye on the rest of the schedule—there’s always a surprise or two.

If you’re after more detailed picks, odds, or just want to nerd out on box score predictions, check out the full article on Bleacher Report.

Joe Hughes
Joe Hughes is the founder of CollegeNetWorth.com, a comprehensive resource on college athletes' earnings potential in the NIL era. Combining his passion for sports with expertise in collegiate athletics, Joe provides valuable insights for athletes, fans, and institutions navigating this new landscape.

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